General
Preferred name
IOX1
Synonyms
IOX 1 ()
IOX-1 ()
Hydroxyqunoline analog 1 ()
IOX1 hydrochloride ()
P&D ID
PD000007
CAS
5852-78-8
878779-63-6
Tags
available
probe
drug candidate
Drug indication
Discovery agent
Probe info
Probe type
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
6
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
IOX1 is a cell-permeable, broad-spectrum 2-oxoglutarate oxygenase inhibitor . This is a compound from the Structural Genomics Consortium's (SGC) Epigenetics Probes Collection.
(GtoPdb)
DESCRIPTION
IOX1, 5-Carboxy-8-hydroxyquinoline, is a potent broad©\spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC50 values of 0.6 ¦ÌM, 2.3 ¦ÌM, 1.8 ¦ÌM, 0.1 ¦ÌM and 1.4 ¦ÌM, respectively[1][2]. IOX1 also inhibits ALKBH5[3].
PRICE
51
DESCRIPTION
Potent and selective ERK2 inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Histone demethylase inhibitor; cell permeable
(Tocriscreen Plus)
DESCRIPTION
IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
IOX1 is the most effective broad-spectrum 2OG oxygenases(including the JmjC demethylases) inhibitor. The IC50 of IOX1 for KDM4A, KDM3A, is 0.6 and 0.1 uM, respectively.
(TargetMol Bioactive Compound Library)
DESCRIPTION
IOX1 is a potent broad‐spectrum inhibitor of 2OG oxygenases. It inhibits Lysine-specific demethylase 3A (IC50 = 0.1 μM), Lysine-specific demethylase 4C (IC50 = 0.6 μM), Lysine-specific demethylase 6B (IC50 = 1.4 μM), Lysine-specific demethylase 2A (IC50 = 1.8 μM).
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
0
Compound Sets
20
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
High-quality chemical probes
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
SGC Probes
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
189.04
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
2
cLogP
1.64
TPSA
70.42
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
Histone Demethylase
JMJC demethylase
KDM4A/KDM3A
EGLN1, KDM3A, KDM4C, KDM6B
Histone Demethylase,JMJD
KDM4A
KDM4C
KDM4D
KDM4E
KDM3A
KDM6B
KDM6A
Primary Target
Histone Demethylases
MOA
Inhibitor
broad-spectrum inhibitor of 2OG oxygenases
Histone Demethylase inhibitor
Member status
member
Pathway
Epigenetics
Chromatin/Epigenetic
Protein Family
KDM
Source data
